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Botox FAQ: myths and facts

Does your face necessarily freeze? Can you become resistant? What happens when you stop? Can a badly placed toxin be removed? Here are the answers to the most frequent questions about botulinum toxin, one by one, with what the official labels really say and what is not yet known.

Some questions about botulinum toxin come up again and again, and the answers that circulate are sometimes approximate, or even wrong. We take them one by one, separating what the official labels and publications say from what is a matter of medical opinion. For the basic concepts, start with our page on what botulinum toxin is and how it is used.

Does Botox necessarily freeze your face?

Not necessarily. The toxin reduces the contraction of the injected muscles; how strong that effect is depends on the dose, the number of injection points and the muscles chosen1,2. An expert consensus stresses the importance of a prior aesthetic assessment and of tailoring treatment area by area8. A frozen look usually reflects a stronger effect than intended, and it is temporary. No study, however, can guarantee a "natural" result: this is a point to discuss with your doctor.

Can you become resistant to botulinum toxin?

It is possible, but rare. The body can produce antibodies that reduce or cancel the effect of the toxin5. Closely spaced injections and high doses make them more likely1,5. In the trials of the short-acting botulinum toxin (serotype E), none of the patients tested developed neutralising antibodies, but data are still limited2. The best way to limit this risk is to respect the intervals set between two sessions.

Is Botox permanent?

No, the effect is always temporary. With a type A toxin, it usually lasts 3–4 months, and up to 6 months for some products1,9. With the short-acting botulinum toxin, it usually lasts 2–3 weeks2. As of 9 October 2026, this toxin is approved in the European Union (since 15 July 2026) and in Canada (since 22 June 2026), for frown lines only10,11. The details are on our page explaining why the effect of the toxin fades over time.

Can you stop the injections?

Yes, at any time. There is no obligation to continue. When the effect fades, the nerve ending recovers its ability to control the muscle, which gradually regains its strength2,7. Lines caused by movement then reappear at the same pace, and the face gradually returns to how it looked before treatment.

Does your face age faster when you stop?

We found no reliable source showing this. What is known is that the effect of the toxin is reversible and that the muscle gradually recovers its activity2,7. The face therefore gradually regains the movement it had before treatment. The idea of accelerated ageing after stopping, like that of a long-term protective effect, is not demonstrated by the sources we consulted.

Can a disappointing result be corrected?

It depends on the problem. An insufficient effect or a slight asymmetry can sometimes be touched up, once the peak effect has been reached, at the doctor’s discretion. An excessive effect, such as a drooping eyelid or eyebrow, is temporary and fades as the nerve recovers7; depending on the problem, the doctor may sometimes suggest a measure to ease it in the meantime. After a short-acting toxin, a type A toxin injected less than 30 days later has not been evaluated2. The SOS section of the site details each problem, area by area.

Can the toxin be removed or dissolved?

No, not once it is working. No product can dissolve or cancel a botulinum toxin that has already bound. Once it has entered the nerve ending, it can no longer be reached by the antibodies that could neutralise it6. An unwanted effect therefore disappears as the nerve recovers7. With the short-acting toxin, whose effect usually lasts 2–3 weeks, this recovery is faster2, but that changes nothing for a type A injection already given.

Why does the toxin sometimes not work?

Several causes are described in the labels. In case of failure, they ask doctors to look at the choice of muscles injected, the injection technique, a dose that is too low or, more rarely, the formation of antibodies3,4. The labels also state that these products must be stored in a refrigerator9. Before concluding that it has failed, you also need to wait for the peak effect, which may only be reached at day 30 with some type A toxins3,4.

Can you have an injection before a wedding?

Yes, provided you plan ahead. It all depends on the timings: with a type A toxin, the peak effect is reached between week 2 and week 41,3; with the short-acting toxin, around day 7, for a duration of 2–3 weeks2. Leaving some margin is useful to judge the result, and the choice is discussed with your doctor. Our page on how fast each type of toxin takes effect details these timings for both families, without recommending one over the other.

Can you switch botulinum toxins?

Yes, but not just any way. The doctor chooses the product. The units of one toxin are not interchangeable with those of another: the dose has to be recalculated2,4. The effect of different serotypes given a short time apart is unknown1, and a type A toxin injected less than 30 days after the short-acting toxin has not been evaluated2. Always mention your last injection and, if possible, the product used.

Are all toxins the same?

No, they are not interchangeable. Each product has its own label, its own dosing unit, its own indications and sometimes its own age limits2,3,4. For example, they are not all approved for the same areas: depending on the product, a type A toxin may also be approved for crow’s feet, or for crow’s feet and the forehead1,4. The short-acting toxin stands out for a faster onset and a shorter duration2. None is better in absolute terms: the choice is made in consultation, and the precautions to take before and after an injection apply whatever the product.

Key points

  • The effect of botulinum toxin is always temporary, and you can stop at any time1,2.
  • Resistance through antibodies is possible but rare, made more likely by high doses and closely spaced sessions5.
  • There is no product to dissolve the toxin: an unwanted effect fades over time6,7.
  • Toxins are not interchangeable: choosing the product and the dose is up to the doctor2,4.

Frequently asked questions

  • Who can perform a botulinum toxin injection?

    A doctor. The labels state that the toxin should only be administered by doctors with the appropriate qualifications and experience of this treatment, and with the necessary equipment4. These medicines are prescription-only. Before the injection, the doctor examines the area, checks for contraindications and explains the possible side effects.

  • Is botulinum toxin a poison?

    In its natural state, yes: botulinum toxins produced by bacteria of the genus Clostridium cause botulism and are among the most potent poisons known6. The medicine is a purified toxin, used in very small doses and injected locally into a specific muscle6. The labels strictly set the doses, which must not be exceeded1.

  • Can you receive two different toxins on the same day?

    The labels do not provide for it. The effect of different serotypes given at the same time or a few months apart is unknown1. The label of the short-acting toxin states that giving it at the same time as another botulinum toxin has not been studied and must be avoided2. Always tell your doctor about a recent injection.

Sources

  1. 1.SmPC of a type A botulinum toxin approved for aesthetic use in France (BDPM, CIS 68150775) (opens in a new tab) — French public medicines database (BDPM)
  2. 2.Summary of product characteristics of the serotype E botulinum toxin approved in the European Union (EPAR annex I) (opens in a new tab) — European Commission (Union Register of medicinal products)
  3. 3.SmPC of a type A botulinum toxin approved for aesthetic use in France (BDPM, CIS 61592762) (opens in a new tab) — French public medicines database (BDPM)
  4. 4.SmPC of a type A botulinum toxin approved for aesthetic use in France (BDPM, CIS 66865211) (opens in a new tab) — French public medicines database (BDPM)
  5. 5.Bellows S., Jankovic J., immunogenicity of botulinum toxins, Toxins, 2019 (opens in a new tab) — Toxins (MDPI)
  6. 6.Pirazzini M. et al., Botulinum neurotoxins: biology, pharmacology, and toxicology, Pharmacological Reviews, 2017 (opens in a new tab) — Pharmacological Reviews
  7. 7.de Paiva A. et al., recovery of the neuromuscular junction after botulinum toxin, PNAS, 1999 (opens in a new tab) — Proceedings of the National Academy of Sciences (PNAS)
  8. 8.Carruthers J. et al., expert consensus on botulinum toxin in facial aesthetics, Plastic and Reconstructive Surgery, 2004 (opens in a new tab) — Plastic and Reconstructive Surgery
  9. 9.SmPC of a type A botulinum toxin approved for aesthetic use in France (BDPM, CIS 65066375) (opens in a new tab) — French public medicines database (BDPM)
  10. 10.European public assessment report (EPAR) of the serotype E botulinum toxin (opens in a new tab) — European Commission (Union Register of medicinal products)
  11. 11.Canadian product monograph of the serotype E botulinum toxin (authorization date: 2026-06-22) (opens in a new tab) — Health Canada
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